Immunohistochemistry showed that SYT17 protein expression was increased in renal tubule cells of the CAAMR group. Recalling that aldosterone increases the excretion of potassium a medication that blocks aldosterone will tend to cause hyperkalemia.
Here we show that synaptotagmin-17 SYT17 is increased in an exosomal fraction of the urine from CAAMR patients and that this increase is associated with activation of the IL-6 amplifier.
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Cause of increased aso titre. Aldosterone also promotes the reabsorption of sodium and water in the renal tubules so spironolactone will tend to cause increased urine output a decreased or normal serum sodium level and signs of dehydration.
Rheumatic Heart Disease Acute Rheumatic Fever